MDA said its paramedics were providing medical care to the two men in their 60s and 30s who had sustained moderate and light wounds, respectively.
The targets struck were sophisticated equipment that Iran could not produce on its own.
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"We are conducting efforts to follow and intercept the target. The public is asked to listen to Home Front Command security guidelines," the IDF said.
Only hours earlier, a senior Hezbollah official had claimed responsibility for the drone attack.
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Prosecutors allege they completed some 600 missions for Iran, including gathering intelligence on sensitive military and infrastructure sites and identifying potential human targets for Iran.
Prof. Amatzia Baram explains how a Hezbollah drone strike near Prime Minister Netanyahu’s residence highlights Iran’s growing influence in the conflict.
UAVs have given Hezbollah the ability to strike buildings in Israel with precision while complicating the detection and interception of these drones.
The tragedy that claimed four soldiers from the IDF's Golani Brigade shows that Israel's defenses are not fully ready to fully combat drone attacks.