The US has expressed a readiness to renew relations with the Islamic Republic, but if talks have no end in sight, it could mean a permanent standoff between Washington and Tehran.
Trump's remarks, said Khamenei, "aren't even worth responding to." They are an "embarrassment to the speaker and the American people."
Tehran would continue Iran-US nuclear talks but is not afraid of threats. "We are not seeking war," he said.
Relations between the E3 and Iran have worsened over the last year despite sporadic meetings, against a backdrop of new sanctions imposed.
After initial success in April, the talks in May have hit a snag. It is not clear if things can be salvaged this week.
Netanyahu managed to turn opposition to the nuclear agreement into a nearly mandatory standard for every Israeli politician.
US Envoy to the Middle East Steve Witkoff echoed similar sentiments in an interview with Breitbart on Friday.
Iran has agreed to hold a fourth round of indirect nuclear talks with the United States on Sunday in Oman.
NATIONAL AFFAIRS: The US president heads to Saudi Arabia, UAE, and Qatar in search of deals and diplomatic wins – leaving Israel out of the itinerary, but not out of the equation.
The site reportedly covers over 2,500 acres, according to the source, and has been operational for over 10 years.