Francis, originally from Argentina, was the first Catholic pontiff from the Americas and began his career as a Jesuit priest in Argentina.
"I appeal to the warring parties: Call a ceasefire, release the hostages and come to the aid of a starving people that aspires to a future of peace," the Pope's Easter message said.
The 88-year-old pontiff, who is limiting his public appearances on doctors' orders, skipped an outdoor ceremony for Good Friday, the day Christians mark Jesus' crucifixion.
The 88-year-old pontiff is gradually making more public appearances as he recovers from the biggest health crisis in his 12 years in the role.
King Charles and Queen Camilla had been due to make a formal state visit to the Vatican, but postponed their plans after doctors prescribed Francis two months of rest.
The pope's official nurse pleaded with doctors to ensure that they did not stop his treatment despite significant risks.
Pope Francis approved a new three-year Vatican reform plan, pushing forward with change despite his ongoing health battle.
Vatican says Pope Francis's health is improving but he remains under close watching Rome's Gemelli hospital.
The pope has not had any new breathing crises, the Vatican announced in a handout.
Francis, 88, has been in Rome's Gemelli hospital for two weeks, after being admitted on February 14 with a severe respiratory infection that triggered other complications.
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