Pope Francis suggested the global community study whether Israel's military campaign in Gaza constitutes a genocide of the Palestinian people.
Francis, originally from Argentina, was the first Catholic pontiff from the Americas and began his career as a Jesuit priest in Argentina.
"I appeal to the warring parties: Call a ceasefire, release the hostages and come to the aid of a starving people that aspires to a future of peace," the Pope's Easter message said.
The 88-year-old pontiff is gradually making more public appearances as he recovers from the biggest health crisis in his 12 years in the role.
King Charles and Queen Camilla had been due to make a formal state visit to the Vatican, but postponed their plans after doctors prescribed Francis two months of rest.
The pope's official nurse pleaded with doctors to ensure that they did not stop his treatment despite significant risks.
The artwork, believed to be the original work of Mantegna, was recently rediscovered in the Sanctuary of Pompeii.
Tradition recounts that Longinus, a Roman centurion, pierced the side of Jesus with this very spear during the crucifixion.
Pope Francis approved a new three-year Vatican reform plan, pushing forward with change despite his ongoing health battle.
The Old Syriac text specifies disciples 'rubbing it in their hands,' highlighting significant nuances in interpretation.