Turkey and Syria broke off diplomatic ties after Assad responded with force to a 2011 uprising against his rule which turned into a civil war.
The earthquake, just like other natural disasters throughout history, could have an impact on international relations, experts say.
The Assad regime is using the situation to pressure for sanctions relief in exchange for allowing aid to arrive in areas of northwestern Syria.
Over 20 Israeli and Turkish organizations will coordinate to deliver food, medicine, clothing, equipment and more to hundreds of thousands of victims.
A lack of water and sanitation, as well as the frigid temperatures, could continue to cost lives in the regions devastated by the earthquake.
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Civilians are reliant on rescue efforts to help bounce back from the devastation of the earthquake.
500 people are entering the hospital daily, but the hospital is running out of medical supplies.
As planes arrive in Damascus, locals and aid organizations are worried about the slow pace of aid and equipment reaching northwest Syria.