Israeli media reported that security forces with water cannons were en route to the Ayalon highway to disperse the crowds.
See no evil: In what universe is there a moral equivalency between ramming a vehicle into people standing at a bus stop and a young person losing his life in a crossfire with terrorists?
The truck driver also struck three men on mopeds who suffered minor injuries, WABC-TV reported.
Politicians around the world and foreign ambassadors in Israel condemned the terror attack in Jerusalem on Friday.
The National Security Minister announced a major operation in east Jerusalem to battle terrorism.
An off-duty police officer and other officers who arrived at the scene quickly after the attack shot the terrorist.
The two IDF reservist soldiers were crossing the road when the driver accelerated and drove into them. The driver says it was a simple car accident due to poor visibility.
The soldier stopped the terror attack while being seriously injured himself.
The driver shouted "anarchists, you ruined the state" as he drove towards the protesters.